To test this hypothesis, we conducted a relatively large-scale case-control study enrolling 432 severe sepsis patients, 384 sepsis patients and 624 healthy individuals to investigate the association of genetic variants in TNF, LTA, TNFRSF1A and TNFRSF1B with severe sepsis susceptibility and prognosis in Chinese Han population. Here, TNFRSF1B is linked to Sepsis.