Several SNPs within the promoter region of TNF (−238, −308, −857, −863, −1031) and the first intron of LTA (+252) were thought to influence TNF-α and LT-α production, and have therefore been identified as candidate variants that might influence susceptibility to and/or outcomes from severe sepsis and infectious diseases [18], [19], [20], [21], [22], [23], [24], [25]. This evidence concerns the gene TNF and infectious disease.