Recent studies proposed that genetic variation in TNFRSF1A and TNFRSF1B was associated with susceptibility to inflammatory and autoimmune diseases, such as tuberculosis, systemic lupus erythematosus, rheumatoid arthritis and Crohn's disease [32], [33], [34], [35]. The gene discussed is TNFRSF1A; the disease is systemic lupus erythematosus.