Amplified genes included several genes (MDM4, PDGFRA, EGFR, CDK4, and MDM2) whose amplification has been previously associated with the pathogenesis of GBM [8], [18], [36], [37]; in addition, other candidate genes were also found to be amplified at both the DNA and RNA levels and thus, to be potentially relevant in the pathogenesis of GBM. This evidence concerns the gene MDM2 and glioblastoma.