Conversely, the role of FAM119B (a gene of unknown function, which has been associated to multiple sclerosis) [49], METLL1 ―a nuclear protein that catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA, inactivated in response to agonists of the PI3-kinase pathway or the classical MAP kinase cascade―, and TSFM (a gene that encodes the mitochondrial translation elongation factor EFTs) in GBM, deserves further investigations. This evidence concerns the gene EEF1AKMT3 and glioblastoma.