Our results show that most genes for which a high correlation was observed between CN alterations and gene expression levels, are coded in those chromosomal regions for which amplicons were detected, pointing out the potential role of several genes coded in chromosomes 12q14(e.g. RAP1B, MDM2 andGRIP1), 4q12 (e.g. TMEM165, FIP1L1 and EXOC1), in addition to the EGFR gene, in GBM. The gene discussed is TMEM165; the disease is glioblastoma.