This is particularly relevant if we consider that the deleted segments at 9p21 encompassed, not only the CDKN2A/B tumor suppressor genes, but also numerous other potentially relevant genes, such as the ELAVL2 (its absence in Drosophyla causes multiple structural defects and hypotrophy of the CNS), KLHL9 [encodes a substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex, required for mitotic progression and cytokinesis], and IFNA (IFNA7, IFNA4, and IFNA17) genes. Here, CUL3 is linked to neoplasm.