Conversely, the role of FAM119B (a gene of unknown function, which has been associated to multiple sclerosis) [49], METLL1 ―a nuclear protein that catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA, inactivated in response to agonists of the PI3-kinase pathway or the classical MAP kinase cascade―, and TSFM (a gene that encodes the mitochondrial translation elongation factor EFTs) in GBM, deserves further investigations. The gene discussed is EEF1AKMT3; the disease is multiple sclerosis.