Since we have previously shown the Shh pathway activation in a panel of human pancreatic cell lines [21], we also sought to examine the effects of SFN on the expression of Shh receptor (Smothened) and effectors (Gli1 and Gli2) by qRT-PCR in pancreatic cancer cells ASPC and PANC-1. This evidence concerns the gene GLI2 and familial pancreatic carcinoma.