Quite interestingly, in line with recent findings associating CMV IgG levels and markers of immunosenescence [53], our data demonstrated a positive association between anti-CMV response and the pro-apoptotic CD95+ CD4+ T-cell compartment in patients with early signs of ATS, lending support to the role of CMV in accelerating immunosenescence. The gene discussed is CD4; the disease is Andersen-Tawil syndrome.