A recent study reported that loss of heterozygosity of CDH1 (E-cadherin) and nuclear localization of β-catenin was associated with down-regulation of E-cadherin in high-grade meningiomas, supporting another molecular mechanism not mediated by transcriptional factors in high-grade meningiomas that induce E-cadherin down-regulation [32]. The gene discussed is CDH1; the disease is meningioma.