We observed significantly different responses between infected and not-infected children with respect to antigens included in the commercially available IGRAs (ESAT-6 and CFP-10), as well as to other mycobacterial antigens (TB 10.3, AlaDH for IFN-gamma and IL-2; HspX and PstS1 only for IL-2 based ELISPOT), but not for Ag86B. This evidence concerns the gene IFNG and tuberculosis.