In contrast, MTTV-Cre-mediated conditional deletion of Pkd1 results in liver cysts by 10 weeks-of-age [25], suggesting that the lack of liver cysts in our study was a consequence of limitations of the Col1a1(3.6)-Cre or the need for additional time for cyst development in the liver. Here, COL1A1 is linked to Hepatic cysts.