Also, consistent with the known gene-dose dependent effect of Pkd1 in cystogenesis that requires a second hit in humans to cause ADPKD, there was no evidence of cysts formation in the pancreas or kidney of heterozygous Col1a1(3.6)-Cre;Pkd1flox/+ mice. The gene discussed is COL1A1; the disease is autosomal dominant polycystic kidney disease.