While the U87 cell showed higher migration and invasion capacity in siRNA-SH3GL2 group than in siRNA-con group (P<0.05) (Figure S2B).These results above strongly suggest that miR-330 is an important factor involved in the migration and invasion of glioblastoma cells by regulating SH3GL2 gene. This evidence concerns the gene SH3GL2 and glioblastoma.