Although she had no definite episode of adrenal insufficiency, longitudinal data showed that her blood cortisol peak, after stimulation by hypoglycemia with insulin tolerance tests, decreased gradually with age (20.5, 17.5, 16.4, and 10.0 μg/dL, at ages of 5, 13, 14, and 15 years, respectively, Ref. The gene discussed is INS; the disease is Hypoglycemia.