Strefford and colleagues reported that chromosome 5 was overrepresented and rearranged in a significant proportion of 19 renal cell carcinoma cell lines, with the genes encoding EGR1 (5q31.1) and CSF1R (Colony-stimulating factor 1 receptor) (5q33–q35) most frequently altered on chromosome 5, further supporting a role for EGR1 in renal cancer [22]. This evidence concerns the gene EGR1 and hereditary clear cell renal cell carcinoma.