Consistently, protein levels of cytosolic β-catenin and canonical Wnt pathway downstream targets c-myc and cyclin D1 were suppressed in these AGS and MKN28 cells infected with Ad-EMX2, but not in AZ521 cells (restoration of EMX2 expression in these cell lines after Ad-EMX2 infection was confirmed by Western) (Figure 5B). The gene discussed is CCND1; the disease is infection.