The mutant intranuclear lamin A/C aggregates caused by the in vitro over-expression of two DCM associated LMNA mutants, p.Asp192Gly-DCM and p.Gln353Lys, as well as the two EDMD-associated LMNA mutants, p.His222Pro and p.Arg386Lys, sequester the sumo1 protein. Here, LMNA is linked to Emery-Dreifuss muscular dystrophy.