We tested the sumoylation of lamin A/C by sumo1 and investigated whether the expression of DCM- and EDMD- associated mutant lamin A and C alter the localization of sumo1 and disturb the sumo1 sumoylation process in the C2C12 mouse myoblast cell model. The gene discussed is SUMO1; the disease is Emery-Dreifuss muscular dystrophy.