We confirmed our results using primary myoblasts isolated from the LmnaH222P/H222P knock-in mouse, which develops adult-onset muscle dystrophy and DCM comparable to the human phenotype [20], and validated the sumo1 mislocalization results in vivo in soleus muscle tissue biopsies from the LmnaH222P/H222P mouse. This evidence concerns the gene SUMO1 and familial dilated cardiomyopathy.