This increased expression of GATA-4 in Sertoli-Leydig cell tumors in comparison to juvenile granulosa cell tumors did not seem to be related to a more aggressive behaviour as expected: there was no apparent correlation between high mitotic rate and GATA-4 expression, whereas detection of a high FOG-2 expression could be linked to a lower tumor stage at diagnosis. The gene discussed is GATA4; the disease is neoplasm.