To further support this hypothesis, we observed that the only tumor presenting a weak positivity for GATA-4 (case 4) showed a mitotic activity superior to 21 mitoses/10 HPF, although none of JGCTs of our series could be considered clinically malignant and considering that mitotic rate is not prognostically relevant in low stage JGCT [2]. The gene discussed is GATA4; the disease is neoplasm.