The phenotypic overlap between embryonic gonad and tumors was observed also in Sertoli-Leydig cell tumors: GATA-4 and FOG-2 pattern of expression replicates the phenotype of Sertoli cells during embryogenesis in the normal testis in which FOG-2 is weakly expressed and GATA-4 more frequently positive [13], [29]. This evidence concerns the gene ZFPM2 and Leydig cell tumor.