Significantly increased GDM risks were found for rs2237892 and rs2237895 of KCNQ1 with per-allele OR of 1.20 (95% CI = 1.09–1.31, P<10−4; Supplementary figure 5) and 1.20 (95% CI = 1.09–1.31, P = 0.0001; Supplementary figure 6) respectively. Here, KCNQ1 is linked to gestational diabetes.