Moreover, recent studies indicate a role for CX3CR1/CX3CL1 in mediating cross-talk between tumor cells and their surrounding microenvironment in models of lymphocytic leukemia, glioblastoma, neuroblastoma, pancreatic cancer, prostate cancer, and breast cancer [26], [27], [28], [29], [30]. Here, CX3CL1 is linked to breast carcinoma.