Moreover, recent studies indicate a role for CX3CR1/CX3CL1 in mediating cross-talk between tumor cells and their surrounding microenvironment in models of lymphocytic leukemia, glioblastoma, neuroblastoma, pancreatic cancer, prostate cancer, and breast cancer [26], [27], [28], [29], [30]. This evidence concerns the gene CX3CL1 and breast cancer.