Moreover, even though the silencing of Cdk5r2 is not inducing beta cell death under normal conditions, we provide evidence that its knock-down by two distinct siRNAs leads to enhanced sensitivity of INS-1E cells exposed to pro-inflammatory cytokines or palmitate, two mediators of beta cell apoptosis in T1D and T2D, respectively [44]. Here, CDK5R2 is linked to type 1 diabetes mellitus.