Additionally, it has been demonstrated that FOXO1-induces G1 phase cell-cycle arrest in renal cell carcinoma and glioma cells due to inhibition of tumor suppressor phosphatase and tensin homolog deleted on chromosome ten (PTEN), via upregulation of the cyclin-dependent kinase inhibitor p27Kip1[20]. Here, CDKN3 is linked to hereditary clear cell renal cell carcinoma.