Ectopic overexpression of FOXO1 (without the 3′UTR) significantly abrogated miR-370-induced proliferation, whereas transfection of the FOXO1 3′UTR (containing the 3′UTR) only partially reduced miR-370-induced proliferation, suggesting that miR-370 increases the proliferation of prostate cancer cells by directly targeting the FOXO1 3′-UTR to downregulate FOXO1. The gene discussed is FOXO1; the disease is Familial prostate cancer.