The Akt/PKB pathway promotes cell survival by regulating a number of transcription factors, including the forkhead transcription factor superfamily [11], such as Forkhead box protein O1 (FoxO1, also known as fork head in rhabdomyosarcomas [FKHR]), FoxO3a (FKHRL1), FoxO4 (AFX) and FoxO6. The gene discussed is FOXO1; the disease is rhabdomyosarcoma.