HPGDS and hematologic disorder: Although the combined effects of different p53 polymorphisms have not been studied, the potential interactions between p53 Arg72Pro polymorphism and other genetic polymorphisms, including those in Murine double minute 2 (MDM2), p73, p21 and Glutathione S-transferase, which are involved in DNA damage repair, apoptosis, cell cycle control, or detoxification of xenobiotic compounds, were found in hematological malignancies [15], [34], [35], [38], [43].