In conclusion, administration of CPEE in this murine asthma model significantly decreased the number of inflammatory cells, particularly eosinophils in BALF and lung tissue, and reduced IL-4 IL-5, IL-13 and eotaxin in BALF and total IgE, OVA-specific IgE and OVA-specific IgG1 levels and AHR in serum after OVA challenge. The gene discussed is IGHE; the disease is asthma.