Since disease prevalence in general rises with increasing age (hypertension, for example has only a 6 percent prevalence rate before age 35 but rises in a linear fashion to 78% in those 75 and older) [31] we would expect a concurrent rise in γ-H2AX foci (Fig. 5, upward arrows and solid line). The gene discussed is H2AX; the disease is Hypertension.