H2AX and hypertensive disorder: The relationship between hypertension and γ-H2AX foci might begin earlier than 57 years of age as we found that analysis of patients 44 years of age and older also revealed a statistically significant (p = 0.020) 33% increase in γ-H2AX foci/cell in hypertension patients over non-hypertensive patients (5.22±0.48 vs. 3.92±0.30, respectively).