In cohort I, there was no significant correlation of pERK in CAFs to major clinico-pathological data such as tumor size, tumor type, Ki-67 status, lymph node status, tumor grade and Her2 but to ERα and progesterone receptor (PR) (P = 0.006 and P = 0.004, respectively, Mann-Whitney U). The gene discussed is ESR1; the disease is neoplasm.