Methods to decrease the severity of allergic reactions include IgE depletion using anti-IgE monoclonal antibodies, induction of IgG blocking antibodies by allergen immunotherapy, and blocking downstream effects of mast cell degranulation using antihistamines or corticosteroids. Controlled oral exposures to allergens have in some cases allowed subjects to develop tolerance, although the mechanisms involved are still under active investigation. However, many asthma patients go on to develop treatment-resistance and disease progression despite optimized treatments, [3], [4]. This evidence concerns the gene IGHE and allergic disease.