One previous meta-analysis also failed to suggest statistically significant associations of IL-1B-511 and IL-1RN VNTR polymorphisms with stroke risk in the overall population, with ORs and 95%CI of 1.22 (0.85–1.87) for TT vs. CC and 1.22 (0.85–1.75) for RN2/RN2 vs. RN1/RN1 [47]. This evidence concerns the gene IL1B and Stroke.