IL1B and coronary artery disorder: Three single nucleotide polymorphisms (SNPs) of the IL-1 gene cluster have been most frequently studied in relation to CHD risk: one SNP at promoter position −511 C/T and another one in exon 5 at position +3954 C/T of the IL-1B gene and a variable number of tandem repeats (VNTR) of 86 bp polymorphism in intron 2 of IL-1RN gene [9], [10], which generates a short allele with two repeats (IL-1RN*2) and long alleles with three to six repeats (IL-1RN L) [10].