Considering that CHD is a multifactorial trait and the impact of the inflammatory cytokine on CHD progress may be modulated by age, gender and some other environmental and genetic factors across different ethnicities, the subgroup analysis based on ethnicity was performed, which showed that IL-1B-511 polymorphism was only associated with CHD in Africans under co-dominant and dominant models, IL-1RN VNTR polymorphism associated in Mixed population under multiplicative, co-dominant and dominant models, respectively. This evidence concerns the gene IL1RN and coronary artery disorder.