SOD2 and colonic neoplasm: However, β-catenin shRNA was found to increase the accumulation of phosphorylated FOXO4 S193 and decrease the expression of FOXO target genes p27Kip1 and MnSOD, which is consistent with an earlier report showing that β-catenin-specific siRNA inhibited TCF reporter activity and FOXO-dependent signaling in LS174 colon cancer cells [19].