The discovery of Megalin as a pathogenic antigen of Heymann Nephritis in rats [11] dates back to 1982, but it is only recently that Megalin was found expressed in human podocytes of Fabry Disease patients [12], meaning that Megalin is probably to be found in human glomeruli too, and may act as a pathogenic antigen. Here, LRP2 is linked to Fabry disease.