Our novel findings suggest that senegenin could improve cognitive impairment through elevating NR2B and rise the possibility that this extract may have some protective effects against neural impairments in POCD, or other neurodegenerative diseases related to NMDA-dependent signaling pathway dysfunction, such as Alzheimer's disease, vascular dementia and age-associated cognitive decline. Here, GRIN2B is linked to neurodegenerative disease.