To determine a differential association of survivin expression with sensitivity to FL118 treatment between cancer cells and non-cancerous cells, we first chose two colon cancer cell lines with different p53 status (HCT-8 with wild type p53 and SW620 with mutant p53) and two non-cancerous cell lines (AHDF and HGF, both with wild type p53) for comparison. This evidence concerns the gene TP53 and cancer.