Somatic and germ-line HRPT2/CDC73 mutations were also commonly found in about 67–100% of sporadic parathyroid carcinomas reported by Shattuck TM (10/15), Howell VM (4/4) and Cetani F (6/7) [10]–[12], but its mutations were found in only 3 among167 cases of parathyroid adenoma [13]. Here, CDC73 is linked to parathyroid gland adenoma.