In this study, we analyzed a series of Chinese patients with clinically non-familial parathyroid carcinoma in an effort to investigate the HRPT2/CDC73 gene mutations and the different immunohistochemical expressions of parafibromin in the PC tissue compared with that in adenoma, hyperplasia and normal tissue of parathyroid glands. This evidence concerns the gene CDC73 and parathyroid gland carcinoma.