In conclusion, validation of the mixed microarray data as it pertains to stromal gene changes via several experimental methodologies performed in vitro and in vivo revealed and confirmed a novel involvement for Peg3, Bmp2k, and Zc3hav1, for the first time, in breast carcinomas where, future studies may reveal direct functions related to modulating the surrounding tumor environment as dictated by decorin. The gene discussed is BMP2K; the disease is breast carcinoma.