Systemic treatment with decorin resulted in an induction of Peg3 (Figure 7A) as well as Bmp2k (Figure 7B) and Zc3hav1 (Figure S2) within the tumor stroma as visualized via immunofluorescence and quantified using three-dimensional surface plots of the fluorescent signal. The gene discussed is ZC3HAV1; the disease is neoplasm.