Analogously, and since decorin is a putative matrix constituent and functions as a soluble paracrine factor on the tumor proper, we sought to identify gene network changes within the broader context of the tumor microenvironment, as this compartment co-evolves with the tumor, following systemic decorin treatment on triple-negative orthotopic breast carcinoma xenograft to gain a better understanding of the molecular interplay evoked by decorin. This evidence concerns the gene DCN and breast carcinoma.