Importantly, the mRNA data for Peg3, Bmp2k, and Zc3hav1 were independently corroborated via immunofluorescence and immunoblotting in not only tumor xenografts but also in co-culture conditions, respectively, and revealed, for the first time, a novel role for Peg3, Bmp2k, and Zc3hav1 in breast cancer progression. The gene discussed is ZC3HAV1; the disease is breast cancer.