TREX1 and Mental deterioration: These related to the genes BTG3 (BTG family, member 3), which is related to prognosis of neuropathic symptoms in paraneoplastic neuropathy [34], TREX1 (three prime repair exonuclease 1), mutations in which can cause a neurovascular disorder involving progressive cognitive decline due to brain degeneration [35], and PTEN (phosphatase and tensin homolog).