Annexin A10 (ANXA10), an overexpressed gene in the oral squamous cell carcinomas (OSCC)-derived cellular lines in our previous microarray data [11], has been implicated in cellular function in endocytosis and exocytosis; anticoagulant activity; interaction with the cytoskeleton; differentiation; and cellular proliferation [12], [13]; and the relevance of malignancy in Barrett's esophagus, gastric cancer, and bladder cancer [14]–[16]. This evidence concerns the gene ANXA10 and esophageal adenocarcinoma.