In particular, a selective loss of excitatory amino-acid transporter 2 (EAAT2), a major glutamate transporter protein located on astrocytes and responsible of up to 94% of glutamate uptake at the synaptic cleft, has been described in ALS patients [29] and other neurodegenerative diseases [30], [31]. This evidence concerns the gene SLC1A2 and neurodegenerative disease.