Studies that have evaluated the correlation of p53-immunoreactivity with clinical outcome have produced conflicting results, and this may have been due to analyses that included different histological subtypes of ovarian cancer as well as incomplete assessment of TP53 mutation status, where mutation status was inferred by immunohistochemistry or where mutation screening was limited to specific exons [6], [45]–[50]. This evidence concerns the gene TP53 and ovarian carcinoma.