In the microSPECT/CT scan of the GBM-bearing mice, high contrast between the sonicated tumor and unsonicated tumor can be seen at 4, 24 and 48 hr after the injection of 111In-Lipo-Dox or 111In-AP-1 Lipo-Dox, especially for 111In-AP-1 Lipo-Dox. Here, DHCR7-DT is linked to neoplasm.