Consistent with this, constitutive activation of IKK2 in intestinal epithelial cells, which is sufficient to induce intestinal tumors in mice, triggers mobilization of macrophages and the expression of a variety of proinflammatory cytokines, including TNF and IL1β [12], and cells with constitutive activation of IKK2 displayed activated Wnt signaling. This evidence concerns the gene IKBKB and intestinal neoplasm.