TNFSF10 and malignant colon neoplasm: We demonstrated that macrophage-derived factors protect colon cancer cells from TRAIL-induced apoptosis through a mechanism dependent on Wnt signaling [13], suggesting that HCT116WT cells (lacking the mutant β-catenin allele), which did not respond to macrophages with enhanced Wnt signaling (Fig. 1), may display an altered response to TRAIL.