Mice adoptively transferred with Cl-IB-MECA-treated CD8+ T cells showed a higher presence of mature LCs that could facilitate the T cell response [34].Transfer of Cl-IB-MECA-treated CD8+ T cells in mice receiving TNF-α mAb led to a reduced activation/influx of mature LCs within tumor tissue, which correlated with an impaired activity of CD8+ T cells to control tumor growth. This evidence concerns the gene TNF and neoplasm.