Since c-MYC activity in macrophages contributes to the acquisition of the M2 phenotype [28], future studies are warranted to assess whether differences in the maturation state of macrophages resulting from c-Myc deficiency affects other pathophysiological processes that are regulated by M2 macrophages, such as parasite encapsulation, angiogenesis, wound healing, fetus rejection, allergy and asthma. This evidence concerns the gene MYC and Allergy.