MYC and neoplasm: In line with in vivo findings, tumor-conditioned medium induced HIF1α, VEGFA and MMP9 expression in control but not in Mφ-c-Myc-KO BMDMs, and wound healing assays showed impaired proliferation and migration of endothelial cells treated with supernatants from Mφ-c-Myc-KO BMDMs exposed to tumor-conditioned medium compared with controls with intact c-Myc.