MYC and allergic disease: Since c-MYC activity in macrophages contributes to the acquisition of the M2 phenotype [28], future studies are warranted to assess whether differences in the maturation state of macrophages resulting from c-Myc deficiency affects other pathophysiological processes that are regulated by M2 macrophages, such as parasite encapsulation, angiogenesis, wound healing, fetus rejection, allergy and asthma.