Importantly, while lovastatin alone did not induce further response except p21 upregulation in normal cells (Figure 5A), it resulted in increased levels of P-ATM, p53 and γ-H2AX in cancer cells (Figure 5B) indicating that lovastatin at the pharmacological relevant concentration of 2 μM per se induces DNA damage in cancer cells. This evidence concerns the gene H2AX and cancer.