Although TLR4 has been reported to be expressed on the surface of most cell types [12], [13], [14], [16], it is also localized in the intracellular compartments of several types of cells including intestinal epithelial cells, placental syncytiotrophoblasts, dendritic cells, and neuroblastoma cells [36], [37], [38]. The gene discussed is TLR4; the disease is neuroblastoma.