As shown in Fig. 9A, SphK inhibitor treated H2691 cells showed decreased promoter histone acetylation of AKB (aurora kinas B, (involved in chromosome segregation and targeted for cancer therapy); Top2A (the DNA unwinding enzyme Topoisomerase 2 alpha); but not that Of HAT1, a known histone acetyltransferase that is elevated in several cancers, and MYST2 [33]. The gene discussed is SPHK1; the disease is cancer.