POMC and Alzheimer disease: In AAs, rare POMC exonic variants were significantly more frequent in SD cases overall or in cases with AD, CD or MjD specifically than in controls (SD: PFET, 1df  = 0.026; AD: PFET, 1df  = 0.027; CD: PFET, 1df  = 0.007; MjD: PFET, 1df  = 0.050).