Zanin-Zhorov et al. indicated that Dlg1 recruitment to the IS was diminished in patients with rheumatoid arthritis, suggesting that Dlg1 function and the regulation of the alternative p38 pathway may contribute to dysregulated Treg cell function in rheumatoid arthritis or human autoimmune conditions [28]. The gene discussed is DLG1; the disease is rheumatoid arthritis.