CHUK and gastric cancer: JAK3, TNFRSF8, and CHUK might affect chronic inflammation and immunity with H. pylori colonization toward gastric cancer, which is important in gastric carcinogenesis as follows: 1) JAK3 is involved in cytokine receptor-mediated intracellular signal transduction, and the cytokine receptor was commonly found in human gastric cancer tissue [30]; 2) TNFRSF8 mediated signal transduction leads to activation of NF-κB [31]; and 3) CHUK is involved in NF-κB signaling pathway activated by H. pylori in gastric cancer cells [32].