In addition, it is not well known whether the genetic variants of the INSL3 gene are linked to gastric carcinogenesis, but the results of this study indicate that at least two SNPs (rs10421916 located in the intron and rs11086080 located in the 3′ of STP) in strong linkage disequilibrium (D′ = 0.86, LOD = 13.42, and r2 = 0.56) appear to have a strong association with a reduced risk for gastric cancer. This evidence concerns the gene INSL3 and gastric cancer.