In the Discovery phase, Six SNPs in four genes (DEFA6, DEFB1, JAK3, and ACAA1) among 1,152 SNPs selected from the innate immunity related genes and 11 SNPs in nine genes (INSL3, CHMP7, CASP7, RAD50, CHUK, TNFRSF8, CD79B, BCL2L11, and CLDN9) among the 1,104 SNPs in 246 NHL-related genes were significantly associated with gastric cancer risk according to the permutated p-values (p<0.01). This evidence concerns the gene DEFA6 and gastric cancer.