In the combined analysis (i.e., pooled and meta analyses) that included the Discovery and Replication phases, two SNPs, DEFA6 rs13275170 and DEFA1 rs2738169 in the innate immunity genes and INSL3 rs10421916 and rs11086080 in the NHL-related genes remained significantly associated with risk for gastric cancer (meta OR = 1.3 [95% CI: 1.1–1.6]; meta OR = 1.3 [95% CI: 1.1–1.5]; meta OR = 0.8 [95% CI: 0.7–0.97]; meta OR = 0.8 [95% CI: 0.7–0.9], respectively). This evidence concerns the gene DEFA1 and gastric cancer.