High levels of IgG and IgG3 against PfRh4.2 were also significantly associated with a reduced risk of high-density parasitemia (defined as >5000 parasites/ul; aHR: 0.51, p = 0.028, and aHR: 0.52, p = 0.027, respectively; Supporting data, Table S1). This evidence concerns the gene IGHG3 and parasitic infectious disease.