In all cells, except those transduced with p519, expression of phosphorylated IκBα peaked within 5–10 minutes of 4-1BBL incubation and IκBα was degraded and undetectable by 15 minutes showing that CD30 D1 and D2D3 independently activate the canonical NF-κB signaling pathway in ALCL cells. The gene discussed is NFKB1; the disease is anaplastic large cell lymphoma.