VEGFC and melanoma: Human modulators of lymphangiogenesis, including an activator (rhVEGF-C) and multiple small molecule inhibitors (hVEGFR-3 inhibitor and rapamycin), reproducibly and specifically altered lymphatic capillary development, and human endothelial and mouse melanoma cells transplanted into zebrafish stimulated a measurable increase in lymphatic capillary growth after suppression with a vegfc morpholino.