Analysis of immunoreactivity against AQP-4, GFAP, and five cytokines (interferon-α, interferon-γ, interleukin-6, interleukin-1α, and IL-12 p35) revealed that none of these proteins showed statistically relevant autoantibody responses in the T1D subjects compared to the controls (Figure S3). The gene discussed is AQP4; the disease is type 1 diabetes mellitus.