The “Replication and Repair” module in turn is connected to cell cycle-related pathways (Cell Cycle, Oocyte meiosis, and p53 signaling pathway) in the “Signal transduction and Cancers” module with 18 out of 31 edges between the “Replication and Repair” and “Signal transduction and Cancers” modules incident to one of the three cell cycle-related pathways. Here, TP53 is linked to cancer.