STAT3 relevance in oncogenesis/tumor progression is widely acknowledged, via regulating apoptosis-related genes (Bcl-XL, Mcl-1 and Survivin) [33], proliferation- (c-myc and cyclin D1) and invasion-promoting genes (VEGF, MMP-9) [34], [35]. The gene discussed is BIRC5; the disease is neoplasm.