We present evidence that overexpression of SOCS3 in HNSCC cell lines that express or do not express endogenous SOCS3 has different impacts on in vitro proliferation and invasion in different HNSCC cell lines and confirm the relevance of subcellular localization of SOCS3 by siRNA experiments in an oral cancer cell line that retains detectable endogenous expression of SOCS3. Here, SOCS3 is linked to head and neck squamous cell carcinoma.