The relationship between SOCS3 expression and OSCC tumor invasion is further supported by our in vitro data, which suggests that overexpression of SOCS3 decreases HNSCC invasion by different mechanisms, affecting primarily migration in cells that do not express detectable endogenous SOCS3 (UM-SCC-22B) and in cells that retain detectable endogenous expression of SOCS3 it may also modulate expression of genes that are important for invasion. Here, SOCS3 is linked to head and neck squamous cell carcinoma.