Our data facilitate the importance of well-known susceptibility genes of osteoporosis such as SOST, COL1A1 and LRP5, and additionally, we detected new candidate genes for further investigations, e.g. MAB21L2. Our study confirms that disturbed bone homeostasis by inhibition of osteogenic regeneration is at least an equally important feature of primary osteoporosis besides enhanced bone resorption. The gene discussed is LRP5; the disease is osteoporosis.